BIEN 670 — Downstream Processing

Introduction to downstream processing (DSP) – principles, characteristics, purpose. Bioprocesses, biomolecules, drug substances, drug products, monoclonal antibodies and Fc fusion proteins, viral vectors, and vaccines. Unit operations - standard practices. Steps and techniques in downstream processing. Harvest and Filtration, Primary capture, Buffer exchange and up-concentration, Purification, Bioconjugation, Formulation. Optimization of downstream processing. Process Analytical Technology (PAT) to support Quality by Design (QbD) in DSP. Regulatory guidelines. Innovative Techniques for Downstream Bioprocessing.

• Credits: 3
• Faculty: Graduate Studies
• Department: Bioengineering
• Taught by: Ayyappasamy Sudalaiyadum Perumal
• Prerequisites: BIEN 590 or permission of the instructor

Sections offered

• Section 001 (Lec), Fri 2:35-5:25 pm — 10 seats open
• Section 002 (Tut), Thu 8:35-11:25 am — 10 seats open