BTEC 650 — Therapeutic Antibody Design

Principles and methodologies of structure-based molecular design, optimization, and development of therapeutic monoclonal antibodies. Role in therapy and diagnosis; structural features of various types of antibodies; dissection of antibody-antigen interactions; in silico affinity maturation; manipulation of antigen specificity by point mutagenesis; using antibody Fc domain to modulate pharmacokinetics and effector functions; design of antibody conjugates carrying toxic payloads; engineering T-cells with chimeric antigen receptors; evaluation and improving antibody immunogenicity and aggregation; antibody humanization.

• Credits: 3
• Faculty: Graduate Studies
• Department: Parasitology
• Taught by: Christopher Corbeil, Reza Salavati, Traian Sulea
• Prerequisite: 400-level or higher level course in biochemistry and bioinformatics, or permission of instructor

Sections offered

• Section 001 (Lec), Tue 9:35 am-12:25 pm — 16 seats open